This report explores the social determinants of health and provides examples of how Economic Development Districts (EDDs) are addressing these factors in their regions through the CEDS, and in areas such as workforce development and job creation, infrastructure, food security, health and prosperity, disaster resilience and public health preparedness, leveraging federal and other sources of funding, data-driven decision-making, and fostering public-private partnerships. It also includes a short case study of how the Land of Sky Regional Council, an EDD serving Western North Carolina, supports individuals seeking to improve their health outcomes.